Publications
Below you can find a list of our published research.
Below you can find a list of our published research.
165 results
JMIR formative research, Volume 8, 15 3 2024, Pages e38803 Use Intention and User Expectations of Human-Supported and Self-Help eHealth Interventions: Internet-Based Randomized Controlled Trial. Cohen Rodrigues TR, Reijnders T, Breeman LD, Janssen VR, Kraaijenhagen RA, Atsma DE, Evers AW
Background: Self-help eHealth interventions provide automated support to change health behaviors without any further human assistance. The main advantage of self-help eHealth interventions is that they have the potential to lower the workload of health care professionals. However, one disadvantage is that they generally have a lower uptake. Possibly, the absence of a relationship with a health care professional (referred to as the working alliance) could lead to negative expectations that hinder... Abstract
Internet interventions, Volume 35, 8 2 2024, Pages 100726 Human cues in eHealth to promote lifestyle change: An experimental field study to examine adherence to self-help interventions. Cohen Rodrigues TR, de Buisonjé DR, Reijnders T, Santhanam P, Kowatsch T, Breeman LD, Janssen VR, Kraaijenhagen RA, Atsma DE, Evers AWM, BENEFIT consortium
eHealth lifestyle interventions without human support (self-help interventions) are generally less effective, as they suffer from lower adherence levels. To solve this, we investigated whether (1) using a text-based conversational agent (TCA) and applying human cues contribute to a working alliance with the TCA, and whether (2) adding human cues and establishing a positive working alliance increase intervention adherence. Participants (N = 121) followed a TCA-supported app-based physical activit... Abstract
Frontiers in nutrition, Volume 10, 22 4 2023, Pages 1178134 Identifying barriers and facilitators to adopting healthier dietary choices in clinical care: a cross-sectional observational study. de Frel DL, Wicks H, Bakk Z, van Keulen N, Atsma DE, Janssen VR
Background and aims: Adopting healthier diets can drastically improve societal health. Our environment plays a crucial role in daily dietary choices and hospitals in particular can stimulate patients to adopt healthier eating habits. Unfortunately, no robust clinically applicable cuing tools exist to help guide in-hospital dietary interventions. The purpose of this study was to identify patient-related barriers and facilitators to adopting healthier dietary choices. Methods and results: This cro... Abstract
Journal of general internal medicine, Volume 39, Issue 4, 22 4 2023, Pages 683-689 How to Use Costs in Value-Based Healthcare: Learning from Real-life Examples. van der Poort EKJ, Kidanemariam M, Moriates C, Rakers MM, Tsevat J, Schroijen M, Atsma DE, van den Akker-van Marle ME, Bos WJW, van den Hout WB
Background: Healthcare organizations measure costs for business operations but do not routinely incorporate costs in decision-making on the value of care. Aim: Provide guidance on how to use costs in value-based healthcare (VBHC) delivery at different levels of the healthcare system. Setting and participants: Integrated practice units (IPUs) for diabetes mellitus (DM) and for acute myocardial infarction (AMI) at the Leiden University Medical Center and a collaboration of seven breast cancer IPUs... Abstract
Cited 1 times since 2023 (1.7 per year) source: EuropePMC
Psychosomatic medicine, Volume 85, Issue 9, 9 2 2023, Pages 795-804 Effectiveness of Human-Supported and Self-Help eHealth Lifestyle Interventions for Patients With Cardiometabolic Risk Factors: A Meta-Analysis. Cohen Rodrigues TR, Breeman LD, Kinik A, Reijnders T, Dusseldorp E, Janssen VR, Kraaijenhagen RA, Atsma DE, Evers AWM, BENEFIT consortium
Objective: eHealth is a useful tool to deliver lifestyle interventions for patients with cardiometabolic diseases. However, there are inconsistent findings about whether these eHealth interventions should be supported by a human professional, or whether self-help interventions are equally effective. Methods: Databases were searched between January 1995 and October 2021 for randomized controlled trials on cardiometabolic diseases (cardiovascular disease, chronic kidney disease, type 1 and 2 diabe... Abstract
European heart journal. Digital health, Volume 4, Issue 4, 7 1 2023, Pages 347-356 Mobile health for cardiovascular risk management after cardiac surgery: results of a sub-analysis of The Box 2.0 study. Biersteker TE, Boogers MJ, Schalij MJ, Braun J, Groenwold RHH, Atsma DE, Treskes RW
Aims: Lowering low-density lipoprotein (LDL-C) and blood pressure (BP) levels to guideline recommended values reduces the risk of major adverse cardiac events in patients who underwent coronary artery bypass grafting (CABG). To improve cardiovascular risk management, this study evaluated the effects of mobile health (mHealth) on BP and cholesterol levels in patients after standalone CABG. Methods and results: This study is a post hoc analysis of an observational cohort study among 228 adult pati... Abstract
Cited 8 times since 2023 (6.3 per year) source: EuropePMC
European journal of preventive cardiology, Volume 30, Issue 3, 1 1 2023, Pages 232-240 Setting your clock: associations between timing of objective physical activity and cardiovascular disease risk in the general population. Albalak G, Stijntjes M, van Bodegom D, Jukema JW, Atsma DE, van Heemst D, Noordam R
Aims: Little is known about the impact of daily physical activity timing (here referred to as 'chronoactivity') on cardiovascular disease (CVD) risk. We aimed to examined the associations between chronoactivity and multiple CVD outcomes in the UK Biobank. Methods and results: physical activity data were collected in the UK-Biobank through triaxial accelerometer over a 7-day measurement period. We used K-means clustering to create clusters of participants with similar chronoactivity irr... Abstract
Clinical nutrition (Edinburgh, Scotland), Volume 42, Issue 1, 17 3 2022, Pages 18-21 An omission in guidelines. Cardiovascular disease prevention should also focus on dietary policies for healthcare facilities. de Frel DL, Assendelft WJJ, Hondmann S, Janssen VR, Molema JJW, Trines SA, de Vries IAC, Schalij MJ, Atsma DE
Suboptimal diet is a major modifiable risk factor in cardiovascular disease. Governments, individuals, educational institutes, healthcare facilities and the industry all share the responsibility to improve dietary habits. Healthcare facilities in particular present a unique opportunity to convey the importance of healthy nutrition to patients, visitors and staff. Guidelines on cardiovascular disease do include policy suggestions for population-based approaches to diet in a broad list of settings... Abstract
PEC innovation, Volume 1, 17 3 2022, Pages 100071 Lifestyle support preferences of patients with cardiovascular diseases: What lifestyle support might work best for whom? Cohen Rodrigues TR, Reijnders T, de Buisonjé DR, Breeman LD, van den Broek I, Janssen VR, Kraaijenhagen RA, Atsma DE, Evers AWM, BENEFIT consortium
Background: Lifestyle support is essential in preventing and treating cardiovascular diseases (CVD), and eHealth may be an easy and affordable solution to provide this support. However, CVD patients vary in their ability and interest to use eHealth. This study investigates demographic characteristics determining CVD patients' online and offline lifestyle support preferences. Methods: We used a cross-sectional study design. 659 CVD patients (Harteraad panel) completed our questionnaire. We a... Abstract
Cited 2 times since 2022 (1.1 per year) source: EuropePMC
JMIR formative research, Volume 6, Issue 7, 28 4 2022, Pages e38263 COVID-box Experiences of Patients and Health Care Professionals (COVID-box Project): Single-Center, Retrospective, Observational Study. Dirikgil E, Brons K, Duindam M, Groeneveld GH, Geelhoed JJM, Heringhaus C, van der Boog PJM, Rabelink TJ, Bos WJW, Chavannes NH, Atsma DE, Teng YKO
Background: During the COVID-19 pandemic, several home monitoring programs have described the success of reducing hospital admissions, but only a few studies have investigated the experiences of patients and health care professionals. Objective: The objective of our study was to determine patients' and health care professionals' experiences and satisfaction with employing the COVID-box. Methods: In this single-center, retrospective, observational study, patients and health care profess... Abstract
Cited 3 times since 2022 (1.6 per year) source: EuropePMC
Frontiers in health services, Volume 2, 8 2 2022, Pages 882964 Optimizing Smoking Cessation Counseling in a University Hospital: Results and Pitfalls. de Frel DL, Janssen VR, Meijer E, Atsma DE
Background: Healthcare professionals (HPs) can play a substantial role in smoking cessation counseling (SCC) but in practice often skip this task due to time constraints. This study evaluates the implementation of the rapid Ask-Advise-Connect (AAC) method in a University hospital setting. Methods: This mixed methods pre-post interventional study was performed at the Cardiology department of a University hospital and consisted of (1) a quantitative assessment of patient smoking registration and H... Abstract
Cited 2 times since 2022 (1 per year) source: EuropePMC
Circulation research, Volume 131, Issue 1, 19 3 2022, Pages 24-41 Sbk2, a Newly Discovered Atrium-Enriched Regulator of Sarcomere Integrity. van Gorp PRR, Zhang J, Liu J, Tsonaka R, Mei H, Dekker SO, Bart CI, De Coster T, Post H, Heck AJR, Schalij MJ, Atsma DE, Pijnappels DA, de Vries AAF
Background: Heart development relies on tight spatiotemporal control of cardiac gene expression. Genes involved in this intricate process have been identified using animals and pluripotent stem cell-based models of cardio(myo)genesis. Recently, the repertoire of cardiomyocyte differentiation models has been expanded with iAM-1, a monoclonal line of conditionally immortalized neonatal rat atrial myocytes (NRAMs), which allows toggling between proliferative and differentiated (ie, excitable and co... Abstract
Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation, Volume 30, Issue 9, 11 2 2022, Pages 431-435 Emergency Heart failure Mortality Risk Grade may help to reduce heart failure admissions. van Hattem NE, Beeres SLMA, Mertens BJA, Antoni ML, Atsma DE, Schalij MJ, den Haan MC
Introduction: Hospital admissions for heart failure (HF) are frequent and pose a heavy burden on health care resources. Currently, the decision to hospitalise is based on clinical judgement rather than on prognostic risk stratification. The Emergency Heart failure Mortality Risk Grade (EHMRG) was recently developed to identify high-risk HF patients in the emergency department (ED). Objective: To assess the ability of the EHMRG to predict 30-day mortality in Dutch HF patients visiting the ED and... Abstract
Cited 2 times since 2022 (0.9 per year) source: EuropePMC
JMIR cardio, Volume 6, Issue 1, 22 4 2022, Pages e29473 A Preoperative Virtual Reality App for Patients Scheduled for Cardiac Catheterization: Pre-Post Questionnaire Study Examining Feasibility, Usability, and Acceptability. Aardoom JJ, Hilt AD, Woudenberg T, Chavannes NH, Atsma DE
Background: Pre- and postoperative anxiety is a common phenomenon associated with negative postoperative outcomes. Symptoms of posttraumatic stress disorder, such as fear, nightmares, and sleep deprivation, are prevalent in approximately 30% to 50% of patients following discharge from intensive care units after cardiac surgery. Preliminary evidence suggests a promising role of virtual reality (VR) in preventing stress-related reactions using stress inoculation training. Such training enables cog... Abstract
Cited 3 times since 2022 (1.3 per year) source: EuropePMC
BMC health services research, Volume 22, Issue 1, 30 5 2022, Pages 129 Clarifying responsibility: professional digital health in the doctor-patient relationship, recommendations for physicians based on a multi-stakeholder dialogue in the Netherlands. Silven AV, van Peet PG, Boers SN, Tabak M, de Groot A, Hendriks D, van Os HJA, Bonten TN, Atsma DE, de Graaf TJ, Sombroek MP, Chavannes NH, Villalobos-Quesada M
Background: Implementation of digital health (eHealth) generally involves adapting pre-established and carefully considered processes or routines, and still raises multiple ethical and legal dilemmas. This study aimed to identify challenges regarding responsibility and liability when prescribing digital health in clinical practice. This was part of an overarching project aiming to explore the most pressing ethical and legal obstacles regarding the implementation and adoption of digital health in... Abstract
The American journal of cardiology, Volume 162, 29 5 2021, Pages 170-176 Value of Global Longitudinal Strain for Identification and Monitoring of Left Ventricular Dysfunction in Becker Muscular Dystrophy. van de Velde NM, Gegenava T, Koeks Z, Butcher SC, Roest AA, Bax JJ, Atsma DE, Spitali P, Ajmone Marsan N, Niks EH
Cardiac involvement is the main cause of death in Becker muscular dystrophy (BMD). Identification of left ventricular (LV) function is crucial, but standard echocardiographic measurements such as LV ejection fraction (LVEF) might not be sensitive enough to detect early myocardial dysfunction. We explored the value of LV global longitudinal strain (GLS) as a more accurate echocardiographic parameter to detect and monitor LV dysfunction in BMD. Furthermore, we studied possible factors associated w... Abstract
Cited 1 times since 2021 (0.4 per year) source: Scopus
Journal of medical Internet research, Volume 23, Issue 10, 15 3 2021, Pages e25646 Facilitators of and Barriers to Lifestyle Support and eHealth Solutions: Interview Study Among Health Care Professionals Working in Cardiac Care. Cohen Rodrigues TR, de Buisonjé DR, Keesman M, Reijnders T, van der Geer JE, Janssen VR, Janssen VR, Kraaijenhagen RA, Atsma DE, Evers AWM
Background: Cardiovascular diseases (CVDs) pose a significant health threat and reduce both people's life expectancy and quality of life. Healthy living is a key component in the effective prevention and treatment of CVD. However, health care professionals (HCPs) experience difficulties in supporting lifestyle changes among their patients. eHealth can provide a solution to these barriers. Objective: This study aims to provide insights into the factors HCPs find important in the support of p... Abstract
Cited 24 times since 2021 (8.7 per year) source: EuropePMC
The European respiratory journal, Volume 58, Issue 2, 5 1 2021, Pages 2100636 Home monitoring reduced short stay admissions in suspected COVID-19 patients: COVID-box project. Dirikgil E, Roos R, Groeneveld GH, Heringhaus C, Silven AV, Petrus AHJ, Villalobos-Quesada M, Tsonaka R, van der Boog PJM, Rabelink TJ, Bos WJW, Chavannes NH, Atsma DE, Teng YKO
Cited 4 times since 2021 (1.4 per year) source: EuropePMC
Journal of cellular and molecular medicine, Volume 25, Issue 16, 30 5 2021, Pages 7772-7782 Phosphorylcholine antibodies restrict infarct size and left ventricular remodelling by attenuating the unreperfused post-ischaemic inflammatory response. Pluijmert NJ, de Jong RCM, de Vries MR, Pettersson K, Atsma DE, Jukema JW, Quax PHA
Phosphorylcholine is a pro-inflammatory epitope exposed on apoptotic cells, and phosphorylcholine monoclonal immunoglobulin (Ig)G antibodies (PC-mAb) have anti-inflammatory properties. In this study, we hypothesize that PC-mAb treatment reduces adverse cardiac remodelling and infarct size (IS) following unreperfused transmural myocardial infarction (MI). Unreperfused MI was induced by permanent ligation of the left anterior descending (LAD) coronary artery in hypercholesterolaemic APOE*3-Leiden... Abstract
Cited 2 times since 2021 (0.7 per year) source: EuropePMC
EJNMMI physics, Volume 8, Issue 1, 16 3 2021, Pages 48 Experimental validation of absolute SPECT/CT quantification for response monitoring in patients with coronary artery disease. van de Burgt A, Dibbets-Schneider P, Slump CH, Scholte AJHA, Atsma DE, de Geus-Oei LF, van Velden FHP
Background: Quantitative SPECT enables absolute quantification of uptake in perfusion defects. The aim of this experimental study is to assess quantitative accuracy and precision of a novel iterative reconstruction technique (Evolution; GE Healthcare) for the potential application of response monitoring using 99mTc-tetrofosmin SPECT/CT in patients with coronary artery disease (CAD). Methods: Acquisitions of an anthropomorphic torso phantom with cardiac insert containing defects (with varying siz... Abstract